Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Generating Electromagnetic Radiations01:10

Generating Electromagnetic Radiations

2.5K
The German physicist Heinrich Hertz (1857–1894) was the first to generate and detect certain types of electromagnetic waves in the laboratory. Starting in 1887, he performed a series of experiments that confirmed the existence of electromagnetic waves and verified that they travel at the speed of light. Hertz used an alternating-current RLC (resistor-inductor-capacitor) circuit that resonated at a known frequency and connected it to a loop of wire. High voltages induced across the gap in...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Economic insecurity is negatively related to cultural engagement.

Scientific reports·2026
Same author

Influence of <i>Lactobacillus acidophilus</i> D2/CSL as a dietary supplement on faecal parameters in rabbits.

Open veterinary journal·2026
Same author

Exploratory values for venous blood gas analysis of clinically healthy Hermann's tortoises (<i>Testudo hermanni</i>).

Frontiers in veterinary science·2026
Same author

malddaba: An open-access database of age-specific mammalian demography for comparative analyses in evolutionary biology and demography.

The Journal of animal ecology·2026
Same author

Data Resource Profile: The Age-It Family Demography Survey (Age-It FDS).

International journal of population data science·2026
Same author

Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state.

Cell reports methods·2026

Related Experiment Video

Updated: May 20, 2025

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers
09:49

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers

Published on: October 23, 2018

15.9K

A compact C-band FLASH electron linear accelerator prototype for the VHEE SAFEST project.

Lucia Giuliano1,2, David Alesini3, Fabio Cardelli3

  • 1Scienze di Base e Applicate per l'Ingegneria (SBAI) Department, Sapienza University of Rome, Rome, Italy.

Frontiers in Oncology
|March 26, 2025
PubMed
Summary
This summary is machine-generated.

This study details a new compact 100 MeV radiation source for advanced cancer treatment. The SAFEST project prototype aims to enable Very High-Energy Electron (VHEE) FLASH therapy for deep-seated tumors.

Keywords:
C-bandFLASH linacFLASH therapyRF designbeam dynamic analysis

More Related Videos

In Situ Transmission Electron Microscopy with Biasing and Fabrication of Asymmetric Crossbars Based on Mixed-Phased a-VOx
09:49

In Situ Transmission Electron Microscopy with Biasing and Fabrication of Asymmetric Crossbars Based on Mixed-Phased a-VOx

Published on: May 13, 2020

4.0K
Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
08:31

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments

Published on: June 27, 2022

1.6K

Related Experiment Videos

Last Updated: May 20, 2025

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers
09:49

An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers

Published on: October 23, 2018

15.9K
In Situ Transmission Electron Microscopy with Biasing and Fabrication of Asymmetric Crossbars Based on Mixed-Phased a-VOx
09:49

In Situ Transmission Electron Microscopy with Biasing and Fabrication of Asymmetric Crossbars Based on Mixed-Phased a-VOx

Published on: May 13, 2020

4.0K
Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
08:31

Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments

Published on: June 27, 2022

1.6K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Accelerator Physics

Background:

  • FLASH therapy offers improved tumor control and reduced healthy tissue damage.
  • Clinical application, particularly for deep tumors, requires Very High-Energy Electron (VHEE) beams (50-250 MeV).
  • The SAFEST project aims to develop a compact C-band 100 MeV radiation source for VHEE FLASH therapy.

Purpose of the Study:

  • To present the design strategy for a C-band linac prototype for VHEE FLASH therapy.
  • To optimize radiofrequency (RF) and electron beam parameters for the prototype.
  • To evaluate the feasibility of a compact C-band VHEE FLASH source.

Main Methods:

  • Development of a C-band linac prototype operating at lower energy.
  • Optimization of electron beam parameters (100 nC pulse, <200 Hz repetition frequency).
  • Analysis of RF and beam dynamics for VHEE generation.

Main Results:

  • Insights into the design and optimization of the linac prototype are provided.
  • Expected dose profiles for the VHEE beam are presented and discussed.
  • The prototype's development demonstrates progress towards a compact C-band VHEE FLASH source.

Conclusions:

  • The SAFEST project's linac prototype is a significant step towards clinical VHEE FLASH therapy.
  • The developed technology facilitates the creation of compact C-band VHEE radiation sources.
  • This innovation holds promise for more effective and targeted cancer treatment.