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Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
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Glomerular filtration rate and comorbidity factors in elderly hospitalizations
1Department of Internal Medicine, Eskişehir City Hospital, Eskişehir 26080, Türkiye. hklncal@hotmail.com.
Background:
With an increase in the elderly population, the frequency of hospitalizations in recent years has also risen at a rapid pace. This, in turn, has resulted in poor outcomes and costly treatments. Hospitalization rates increase in elderly patients due to a decline in glomerular filtration rate (GFR).
Aim:
To investigate the connection between GFR and comorbidity and reasons for hospitalization in elderly patients.
Methods:
We analyzed patients aged 75 years and over who were admitted to the internal medicine clinic of a tertiary hospital in Eskisehir. At admission, we calculated GFR values using the Modification of Diet in Renal Disease study formula and classified them into six categories: G1, G2, G3a, G3b, G4, and G5. We analyzed associations with hospitalization diagnoses and comorbidity factors.
Results:
The average age of the patients was 80.8 years (± 4.5 years). GFR was 57.287 ± 29.5 mL/kg/1.73 m2 in women and 61.3 ± 31.5 mL/kg/1.73 m2 in men (P = 0.106). Most patients were admitted to the hospital at G2 stage (32.8%). The main reasons for hospitalization were anemia (34.4% and 28.6%) and malnutrition (20.9% and 20.8%) in women and men, respectively (P = 0.078). The most frequent comorbidity leading to hospitalization was arterial hypertension (n = 168, 28%), followed by diabetes (n = 166, 27.7%) (P = 0.001).
Conclusion:
When evaluating geriatric patients, low GFR alone does not provide sufficient information. Patients' comorbid factors should also be taken into account. There is no association between low GFR during hospitalization and hospitalization-related diagnoses. Knowing the GFR value before hospitalization will be more informative in such studies.
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