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Updated: May 20, 2025

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
Published on: July 18, 2019
Application and Progression of Single-Cell RNA Sequencing in Diabetes Mellitus and Diabetes Complications
Jiajing Hong1, Shiqi Lu1, Guohui Shan2
1College of Acupuncture and Massage, Changchun University of Chinese Medicine, Changchun, China.
Abstract:
Diabetes is a systemic metabolic disorder primarily caused by insulin deficiency and insulin resistance, leading to chronic hyperglycemia. Prolonged diabetes can result in metabolic damage to multiple organs, including the heart, brain, liver, muscles, and adipose tissue, thereby causing various chronic fatal complications such as diabetic retinopathy, diabetic cardiomyopathy, and diabetic nephropathy. Single-cell RNA sequencing (scRNA-seq) has emerged as a valuable tool for investigating the cell diversity and pathogenesis of diabetes and identifying potential therapeutic targets in diabetes or diabetes complications. This review provides a comprehensive overview of recent applications of scRNA-seq in diabetes-related researches and highlights novel biomarkers and immunotherapy targets with cell-type information for diabetes and its associated complications.
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