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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Updated: May 20, 2025

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

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Published on: March 15, 2019

Biostimulatory Fillers to Treat Post-liposuction Skin Irregularities.

Stefania Guida¹, Ilaria Proietti², Claudio Conforti³

¹Dr. Guida is with the School of Medicine at Vita-Salute San Raffaele University in Milan, Italy, and the Dermatology Clinic at IRCCS San Raffaele Hospital in Milan, Italy.

The Journal of Clinical and Aesthetic Dermatology

|March 26, 2025

Summary

Calcium hydroxylapatite (CaHA) injections effectively treat post-liposuction skin irregularities (PLSI), improving depression depth and skin laxity. This study suggests CaHA is a safe and viable option for managing PLSI.

Keywords:

PLSI scale Post-liposuction skin irregularities biostimulation calcium hydroxyapatite liposuction

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Published on: January 7, 2015

Area of Science:

Aesthetic Medicine
Dermatology
Regenerative Medicine

Background:

Post-liposuction skin irregularities (PLSI) present a common clinical challenge.
Increasing patient demand necessitates effective PLSI treatment options.

Purpose of the Study:

To evaluate the efficacy and safety of calcium hydroxylapatite (CaHA) for treating PLSI.
To assess CaHA's impact on skin depressions and laxity post-liposuction.

Main Methods:

Retrospective analysis of eight PLSI areas in six female patients treated with diluted/hyperdiluted CaHA.
Efficacy assessment using pre- and post-treatment photographs evaluated with the PLSI scale.
Safety evaluation based on recorded adverse events.

Main Results:

Statistically significant improvement in the number and depth of skin depressions.
Observed trend towards reduction in skin laxity.
CaHA demonstrated a favorable safety profile with no major adverse events reported.

Conclusions:

Diluted/hyperdiluted CaHA shows promise as an effective and safe treatment for PLSI.
Further larger-scale studies are recommended to validate these preliminary findings.