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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

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Published on: June 19, 2019

Thalamic Stroke and Sleep Study: Sleep-Wake, Autonomic Regulation, and Cognition.

Irina Filchenko^1,2,3, Aleksandra Katarzyna Eberhard-Moscicka^1,4, Jasmine Lea Picard^1,2

¹Department of Neurology, Bern University Hospital (Inselspital) and University of Bern, Switzerland.(I.F., A.K.E.-M., J.L.P., M.H.S., M.A.S., C.B., C.L.A.B.).

|March 26, 2025

Summary

Thalamic stroke (TS) disrupts sleep, cognition, and autonomic function. Lesions in the thalamus, particularly the mediodorsal nucleus, correlate with specific sleep and memory deficits, highlighting the thalamus’s regulatory role.

Keywords:

cognition memory sleep stroke thalamus

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Area of Science:

Neuroscience
Sleep Medicine
Neurology

Background:

Thalamic stroke (TS) presents complex symptoms including sleep disturbances, cognitive deficits, and autonomic dysregulation.
The intricate interactions between these functional alterations post-TS are not well understood.

Purpose of the Study:

To investigate the interactions between sleep-wake, autonomic, and cognitive functions in patients with thalamic stroke.
To explore the relationship between lesion location within the thalamus and observed functional deficits.

Main Methods:

A case-control lesion study involving 16 patients with acute TS and 32 healthy controls.
Assessment included sleep-wake variables (polysomnography, actigraphy, questionnaires), nocturnal heart rate variability, and cognitive tests (processing speed, memory, attention).
Data collected prospectively from June 2020 to September 2022.

Main Results:

TS patients exhibited prolonged sleep duration and increased parasympathetic-dominant heart rate variability.
EEG alterations included reduced cyclic alternating pattern index, slow spindle density, and alpha-band spectral power.
Mediodorsal nucleus lesions were linked to decreased sleep spindle/slow wave amplitude and increased REM sleep, alongside deficits in processing speed, working memory, and verbal memory.

Conclusions:

The thalamus plays a critical role in regulating integrated sleep-wake, autonomic, and cognitive functions.
Findings support the thalamus as a key regulator of these interconnected functions.
These results provide a theoretical foundation for thalamus-targeted therapeutic strategies.