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Exploring the Link Between C-Reactive Protein Change and Stroke Risk: Insights From a Prospective Cohort Study and

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Changes in C-reactive protein (CRP) levels are linked to increased stroke risk. Elevated or persistently high CRP levels significantly raise the risk of any stroke, ischemic stroke, and hemorrhagic stroke.

Keywords:
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Area of Science:

  • Biomedical research
  • Cardiovascular epidemiology
  • Inflammation markers

Background:

  • Limited prior research exists on C-reactive protein (CRP) changes predicting stroke risk.
  • This study addresses the gap by examining the association between CRP level fluctuations and stroke incidence.

Purpose of the Study:

  • To investigate the relationship between changes in CRP levels and the risk of overall stroke and its specific subtypes.
  • To explore the genetic underpinnings of the CRP-stroke association.

Main Methods:

  • Utilized UK Biobank data from 14,754 participants with a median follow-up of 10.4 years.
  • Employed Cox proportional hazards regression for association analysis.
  • Conducted genetic analyses including genetic correlation, GWAS, and polygenic risk scores.

Main Results:

  • Elevated CRP percentage change correlated with higher risks of any stroke (HR 1.44) and ischemic stroke (HR 1.65).
  • Participants with newly elevated or persistently high CRP levels showed increased risks for any stroke and ischemic stroke.
  • Persistently high CRP levels were associated with a heightened risk of hemorrhagic stroke (HR 1.91).
  • Significant genetic correlation (r_g=0.257) and 5 shared genomic regions were identified between CRP and stroke.
  • High stroke polygenic risk scores combined with elevated or high CRP levels indicated the highest stroke risk.

Conclusions:

  • Both any stroke and ischemic stroke are associated with elevated and persistently high C-reactive protein levels.
  • Persistently high CRP levels are specifically linked to an increased risk of hemorrhagic stroke.