Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereoisomerism02:52

Stereoisomerism

11.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
11.7K
Structural Isomerism02:34

Structural Isomerism

19.1K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly,...
19.1K
Solvating Effects02:12

Solvating Effects

7.2K
An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
7.2K
Isomerism02:43

Isomerism

17.8K
Isomers are molecules with the same molecular formula but different structural arrangements. Isomers can be further classified into constitutional isomers and stereoisomers. Constitutional isomers differ in the connectivity of their constituent atoms. For example, 2-butanol and diethyl ether are constitutional isomers, as they have the same chemical formula, C4H10O, but differ in the connectivity of the carbon and oxygen atoms. Constitutional isomers have different physical and chemical...
17.8K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

8.6K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
8.6K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

5.7K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting halide-receptor interactions in "four wall" aryl-extended calix[4]pyrrole complexes: the role of the aromatic walls.

Physical chemistry chemical physics : PCCP·2026
Same author

Selectivity in gas-liquid interactions: Molecular beam scattering of CD4 and ND3 from an aqueous flat liquid jet.

The Journal of chemical physics·2026
Same author

Messenger Tagging Vibrational Spectroscopy of Protonated Nicotinamide.

The journal of physical chemistry. A·2025
Same author

Optical Properties of CdSe/CdZnS Core/Shell Nanoplatelets at High Pressure.

Journal of the American Chemical Society·2025
Same author

X-ray photoelectron spectroscopy of surfactants on sub-micron aqueous aerosols.

Physical chemistry chemical physics : PCCP·2025
Same author

Probing Isomers and Conformers by Cryogenic Ion Vibrational Spectroscopy: Deprotonated States of Valine and Aminovaleric Acid.

The journal of physical chemistry. A·2025

Related Experiment Video

Updated: May 20, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.0K

Isomerism and Solvent Interaction in Octamethyl Calix[4]pyrrole Complexed with Formate.

Lane M Terry1, Madison M Foreman1, J Mathias Weber1

  • 1JILA and Department of Chemistry, University of Colorado, 440 UCB, Boulder, Colorado 80309-0440, United States.

The Journal of Physical Chemistry. B
|March 26, 2025
PubMed
Summary

Octamethyl calix[4]pyrrole (omC4P) forms host-guest complexes with formate anions. Complex binding behaviors and multiple low-energy isomers were observed, influencing spectral features.

More Related Videos

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

6.8K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

10.6K

Related Experiment Videos

Last Updated: May 20, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.0K
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

6.8K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

10.6K

Area of Science:

  • Supramolecular Chemistry
  • Physical Chemistry
  • Spectroscopy

Background:

  • Octamethyl calix[4]pyrrole (omC4P) is a well-known anion receptor.
  • Understanding host-guest interactions is crucial in supramolecular chemistry.
  • Formate anion binding can exhibit complex behaviors due to its charge distribution.

Purpose of the Study:

  • To investigate the binding motifs of octamethyl calix[4]pyrrole (omC4P) with the formate anion.
  • To explore the influence of solvent on the host-guest complex.
  • To characterize the structural and electronic properties of the formate-omC4P complex.

Main Methods:

  • Cryogenic ion vibrational spectroscopy (CIVS) was employed to study the complexes.
  • Density functional theory (DFT) calculations were used to complement experimental data.
  • Infrared spectra were analyzed in vacuo and in two different solvent environments (deuterated acetonitrile and acetone).

Main Results:

  • Three low-energy isomers of the formate-omC4P complex were identified in vacuo.
  • Complex behavior of NH stretching features was observed, influenced by host-guest interactions and solvent effects.
  • The binding geometries lowered the C4v symmetry of the omC4P receptor to C1, Cs, or C2v.

Conclusions:

  • The study reveals intricate binding modes between omC4P and formate, leading to isomerism.
  • Symmetry breaking and isomerism significantly impact the observed spectral patterns.
  • Solvent polarity plays a role in modulating the host-guest complex behavior.