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Updated: May 20, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Maternal Early-onset Preeclampsia Places Preterm Infants at Risk of Thrombocytopenia Requiring Platelet Transfusions

Joana Pereira1, David Rabiço-Costa1,2, Mariana Marques1

  • 1Department of Gynecology-Obstetrics and Pediatrics, Faculty of Medicine of University of Porto.

Journal of Pediatric Hematology/Oncology
|March 26, 2025
PubMed

Insights

Infants born to mothers with early-onset preeclampsia (PE) required more platelet transfusions, increasing risks. This study evaluated hematological parameters in very premature infants on their first day of life.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Perinatology

Background:

  • Preeclampsia (PE) is associated with hematological changes in newborns, though findings are inconsistent.
  • Early-onset PE poses significant risks to maternal and neonatal health.

Purpose of the Study:

  • To evaluate hematological parameters in very premature infants born to mothers with early-onset preeclampsia (PE) on day of life 1 (D1).
  • To determine the correlation between these hematological parameters and neonatal morbimortality.

Main Methods:

  • Retrospective study (2008-2023) at a level III NICU.
  • Included preterm infants (<30 weeks gestational age).
  • Compared hematological parameters on D1 between infants exposed and not exposed to PE.

Main Results:

  • No significant differences in overall hematological parameters were found between groups.
  • Infants exposed to PE required significantly more platelet transfusions (51.8% vs. 20.36%).

Conclusions:

  • Early-onset preeclampsia exposure in very premature infants necessitates increased platelet transfusions.
  • This increased need for transfusions elevates the risk of associated neonatal complications.
Abstract

Keywords:
hematologic parametersplatelet transfusionpreeclampsiapreterm infantthrombocytopenia

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