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Eirini Kavvalou1,2, Maria Polina Konstantinou1,2, Sabine Kruger-Krasagakis1,2

  • 1School of Medicine, University of Crete, Heraklion, Greece.

Journal of the European Academy of Dermatology and Venereology : JEADV
|March 26, 2025
PubMed
Abstract

No abstract available in PubMed .

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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