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Research Progress on the Relationship Between PRPF8 and Cancer

Guoqing Huang1, Dandan Wang1, Jiaying Xue1

  • 1Institute of Advanced Technology, Heilongjiang Academy of Sciences, Harbin 150001, China.

Current Issues in Molecular Biology
|March 26, 2025
PubMed

Insights

Alternative splicing (AS) is vital for gene expression and cancer. Protein pre-mRNA processing factor 8 (PRPF8) mutations drive cancer by altering AS, impacting progression and drug resistance.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Alternative splicing (AS) regulates gene expression and protein diversity.
  • Protein pre-mRNA processing factor 8 (PRPF8) is essential for spliceosome function and accurate gene transcription.
  • PRPF8 dysfunction is implicated in various cancers due to its role in aberrant splicing.

Purpose of the Study:

  • To review the mechanisms of PRPF8-mediated alternative splicing in tumorigenesis.
  • To explore PRPF8's role in diverse cancer types and associated molecular pathways.
  • To discuss the therapeutic potential and challenges of targeting PRPF8 in cancer treatment.

Main Methods:

  • Literature review of studies on PRPF8, alternative splicing, and cancer.
  • Analysis of molecular pathways involved in PRPF8 dysregulation.
  • Examination of PRPF8's role in breast, liver, myeloid, and colorectal cancers.

Main Results:

  • PRPF8 mutations lead to abnormal splicing, promoting tumorigenesis, metastasis, and drug resistance.
  • Dysregulation of PRPF8 impacts multiple cancer types through specific molecular pathways.
  • PRPF8's involvement in cancer progression is multifaceted, affecting gene expression and protein function.

Conclusions:

  • PRPF8 is a critical regulator of alternative splicing with significant implications in cancer development.
  • Targeting PRPF8 presents a potential therapeutic strategy for various cancers.
  • Further research is needed to overcome challenges in developing PRPF8-targeted cancer therapies.
Keywords:
PRPF8alternative splicingcancer

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