Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Probiotics01:22

Probiotics

296
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
296
The Skin Microbiota01:27

The Skin Microbiota

123
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
123
Acne Infection01:27

Acne Infection

94
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
94
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

90
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxadiazolone Derivatives: Powerful Tools to Reduce <i>Staphylococcus aureus</i> Infection.

ACS infectious diseases·2026
Same author

Synthesis and QSAR Studies of Claramine Derivatives, a New Class of Broad-Spectrum Antimicrobial Agents.

Molecules (Basel, Switzerland)·2025
Same author

Permeabilize, but Choose Wisely: Selective Antibiotic Potentiation Through Outer Membrane Disruption in <i>Pseudomonas aeruginosa</i>.

International journal of molecular sciences·2025
Same author

Efflux-Mediated Resistance in <i>Enterobacteriaceae</i>: Recent Advances and Ongoing Challenges to Inhibit Bacterial Efflux Pumps.

Antibiotics (Basel, Switzerland)·2025
Same author

Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative.

Biomolecules·2025
Same author

Bioinspired Syntheses of the Marine Pyridoacridine Alkaloids 2-Bromo and 3-Bromodeoxyamphimedine and Structure Correction of 2-Bromoamphimedine.

Journal of natural products·2025

Related Experiment Video

Updated: May 5, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

9.9K

Linoleic Fatty Acid from Rwandan Propolis: A Potential Antimicrobial Agent Against Cutibacterium acnes.

Florent Rouvier1,2, Lydia Abou3, Emmanuel Wafo1

  • 1INSERM, SSA, MCT, Aix Marseille Université, 13385 Marseille, France.

Current Issues in Molecular Biology
|March 26, 2025
PubMed
Summary

Linoleic acid from Rwandan propolis effectively inhibits acne-causing bacteria (C. acnes) at low concentrations. This natural compound shows promise for developing new topical acne treatments due to its antimicrobial and membrane-disrupting properties.

Keywords:
Cutibacterium acnesacneantibacterial activityfatty acidslinoleic acidpropolis

More Related Videos

Extraction and Analysis of Taiwanese Green Propolis
06:50

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

8.4K
Isolation of Lipoprotein Particles from Chicken Egg Yolk for the Study of Bacterial Pathogen Fatty Acid Incorporation into Membrane Phospholipids
11:59

Isolation of Lipoprotein Particles from Chicken Egg Yolk for the Study of Bacterial Pathogen Fatty Acid Incorporation into Membrane Phospholipids

Published on: May 15, 2019

9.6K

Related Experiment Videos

Last Updated: May 5, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

9.9K
Extraction and Analysis of Taiwanese Green Propolis
06:50

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

8.4K
Isolation of Lipoprotein Particles from Chicken Egg Yolk for the Study of Bacterial Pathogen Fatty Acid Incorporation into Membrane Phospholipids
11:59

Isolation of Lipoprotein Particles from Chicken Egg Yolk for the Study of Bacterial Pathogen Fatty Acid Incorporation into Membrane Phospholipids

Published on: May 15, 2019

9.6K

Area of Science:

  • Dermatology
  • Microbiology
  • Natural Products Chemistry

Background:

  • Acne vulgaris affects 80% of adolescents, with increasing resistance to antibiotics like erythromycin.
  • Existing treatments for acne vulgaris show variable efficacy.
  • Natural compounds are being explored as alternatives to conventional acne therapies.

Purpose of the Study:

  • To investigate the antimicrobial activity of Rwandan propolis extract against Cutibacterium acnes (C. acnes).
  • To identify specific compounds within propolis with significant C. acnes inhibitory effects.
  • To elucidate the mechanism of action of identified active compounds.

Main Methods:

  • Propolis collected in Rwanda was extracted and fractionated.
  • Antimicrobial activity against C. acnes was assessed using NCLSI guidelines.
  • Linoleic acid's effect on C. acnes growth and membrane permeability (using Bacillus cereus and ATP assay) was evaluated.

Main Results:

  • Linoleic acid demonstrated significant inhibition of C. acnes growth at a concentration of 16 µg/mL.
  • Linoleic acid exhibited a specific membranotropic effect on Bacillus cereus, indicating membrane disruption.
  • Comparison with other fatty acids highlighted linoleic acid's unique antimicrobial action.

Conclusions:

  • Linoleic acid is a potent inhibitor of C. acnes growth.
  • The membranotropic activity of linoleic acid suggests a novel mechanism for combating acne-causing bacteria.
  • Linoleic acid from propolis is a promising candidate for developing natural, effective acne treatments.