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The Gut Microbiota and Colorectal Cancer: Understanding the Link and Exploring Therapeutic Interventions
Imen Zalila-Kolsi1, Dhoha Dhieb2, Hussam A Osman1
1Faculty of Medical and Health Sciences, Liwa College, Abu Dhabi P.O. Box 41009, United Arab Emirates.
Biology
|March 26, 2025
Summary
Gut microbiota imbalances (dysbiosis) impact colorectal cancer (CRC) development and treatment. Restoring microbial balance through interventions may improve CRC patient outcomes and offers new diagnostic and prognostic tools.
Area of Science:
- Oncology
- Microbiology
- Gastroenterology
Background:
- Colorectal cancer (CRC) presents a significant public health challenge with high prevalence and mortality.
- The gut microbiota plays a crucial role in CRC pathogenesis and influences treatment efficacy.
- Microbial community imbalances (dysbiosis) are linked to CRC progression and therapeutic outcomes.
Purpose of the Study:
- To review the complex relationship between gut microbiota composition and CRC.
- To explore the potential of microbial profiles as biomarkers for CRC early detection and prognosis.
- To discuss interventions aimed at modulating the gut microbiota for improved CRC management.
Main Methods:
- Literature review of studies investigating the gut microbiome in colorectal cancer.
- Analysis of research on microbial dysbiosis and its impact on CRC.
- Examination of various microbiota-targeted interventions and their clinical applications.
Main Results:
- Gut microbiota composition is intricately linked to CRC development and progression.
- Microbial profiles show potential as biomarkers for CRC diagnosis and prognosis.
- Interventions like prebiotics, probiotics, and dietary changes can restore microbial balance.
- Intratumoral microbiota analysis, combined with AI, may predict treatment response and adverse effects.
Conclusions:
- Modulating the gut microbiota holds promise for CRC prevention and treatment.
- Personalized, microbiota-oriented strategies can enhance patient care and clinical outcomes in oncology.
- Integrating microbial profiling into clinical practice can improve diagnostic capabilities and treatment personalization.
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