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Published on: June 7, 2015
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Cyclodextrin-Hydrogel Hybrids in Advanced Drug Delivery.
Hossein Omidian1, Arnavaz Akhzarmehr1, Erma J Gill1
1Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Gels (Basel, Switzerland)
|March 26, 2025
Summary
Cyclodextrin (CD)-hydrogel hybrids enhance drug delivery by improving solubility and controlled release. Challenges include scalability and clinical translation, requiring further research into smart hydrogels and validation.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Cyclodextrin (CD)-hydrogel hybrids combine CD inclusion complexation with hydrogel properties for advanced drug delivery.
- These systems address limitations of conventional formulations by enhancing drug solubility, controlling release, and improving bioavailability.
Purpose of the Study:
- To review the composition, fabrication, and applications of CD-hydrogel drug delivery systems.
- To discuss advancements in stimuli-responsive hydrogels, nanogels, and microneedle-based delivery.
- To identify challenges and future research directions for CD-hydrogel systems.
Main Methods:
- Literature review focusing on CD-hydrogel hybrid systems.
- Analysis of factors influencing drug release kinetics.
- Exploration of therapeutic applications and emerging technologies.
Main Results:
- CD-hydrogel hybrids offer versatile drug delivery with enhanced solubility and controlled release.
- Key factors influencing drug release include CD type, hydrogel composition, and fabrication methods.
- Recent advancements include stimuli-responsive systems, nanogels, and microneedles.
Conclusions:
- CD-hydrogel systems show significant therapeutic potential but face challenges in scalability and clinical translation.
- Future research should prioritize smart hydrogels, optimized drug loading, and robust clinical validation.
- Bridging the gap between lab innovations and commercial applications is crucial for widespread adoption.
Keywords:
Cyclodextrin hydrogelsbiocompatibilitycontrolled releasedrug delivery systemssolubility enhancementMore Related Videos
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