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Serum ferritin assay.

C P Alfrey1

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

CRC Critical Reviews in Clinical Laboratory Sciences
|January 1, 1978
PubMed
Summary
This summary is machine-generated.

Serum ferritin concentration, measured by a sensitive immunoradiometric assay, accurately reflects total body iron stores. This assay is valuable for diagnosing iron deficiency anemia and other disorders.

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Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Chemistry

Background:

  • Ferritin is a high-molecular-weight iron storage protein found mainly in the liver, spleen, and bone marrow.
  • Accurate measurement of serum ferritin is crucial for assessing iron status and diagnosing related disorders.

Purpose of the Study:

  • To describe a sensitive immunoradiometric assay for determining serum ferritin concentrations.
  • To evaluate the utility of this assay in clinical medicine and public health.

Main Methods:

  • Development of a highly sensitive immunoradiometric assay for serum ferritin.
  • Correlation of serum ferritin levels with total body iron stores measured by phlebotomy in normal subjects.
  • Analysis of serum ferritin levels in patients with iron-deficient anemia and other anemias.

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Main Results:

  • Serum ferritin concentration in normal subjects strongly correlates with total body iron stores.
  • Reduced serum ferritin levels are observed in patients with iron-deficient anemia.
  • Significantly elevated serum ferritin levels are found in patients with anemia due to other causes.

Conclusions:

  • The developed immunoradiometric assay is sensitive and accurate for measuring serum ferritin.
  • Serum ferritin levels are a reliable indicator of total body iron stores.
  • This assay is a valuable tool for diagnosing and managing various clinical disorders, particularly anemias.