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Low-Cost, Open-Source, High-Precision Pressure Controller for Multi-Channel Microfluidics.

Mart Ernits1, Olavi Reinsalu1, Andreas Kyritsakis1

  • 1Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.

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|March 26, 2025
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Summary
This summary is machine-generated.

This study presents an open-source, custom-built pressure controller for microfluidics. The device offers precise pressure regulation at a lower cost, proving feasible for advanced microfluidic applications.

Keywords:
Arduinoliposomesmicrofluidicspressure controller

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Area of Science:

  • Engineering
  • Biotechnology
  • Physics

Background:

  • Microfluidics requires precise control of fluid flow at low volumes.
  • Existing pressure control systems can be expensive and lack customizability.

Purpose of the Study:

  • To develop and validate a cost-effective, open-source pressure controller for microfluidic systems.
  • To demonstrate the device's performance in advanced microfluidic applications.

Main Methods:

  • Design and construction of a custom pressure controller utilizing piezoelectrically controlled valves.
  • Open-source system architecture for high user customizability.
  • Performance validation through pressure accuracy and stability measurements.

Main Results:

  • The custom pressure controller demonstrates high accuracy, with output pressure varying less than 0.7% from reported values (-380 to 380 mbar).
  • Exceptional stability was observed, with output pressure fluctuating only ±0.2 mbar during pressure cycling (10 to 500 mbar).
  • The device is approximately one-third the cost of comparable commercial alternatives.

Conclusions:

  • The developed pressure controller is highly accurate, stable, and cost-effective.
  • Its open-source nature and performance make it suitable for advanced low-pressure microfluidic applications.
  • Successful application in microfluidic hydrodynamic focusing for large unilamellar vesicle synthesis validated its utility.