Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 20, 2025

Ultrasonic Assessment of Myocardial Microstructure

Ultrasonic Assessment of Myocardial Microstructure

Published on: January 14, 2014

Evaluating Epicardial Fat Density Using ROI-Based Analysis: A Feasibility Study.

Giovanni Lorusso¹, Nicola Maggialetti¹, Luca De Marco¹

¹Section of Radiology and Radiation Oncology, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Journal of Cardiovascular Development and Disease

|March 26, 2025

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Coronary Artery Anomalies and Anatomical Variants: Cross-Sectional Diagnostic Imaging and Clinical Background.

Journal of imaging·2026

Same author

Diagnostic performance of the NI-RADS system for detecting recurrence in head and neck squamous cell carcinoma: a monocentric pilot study.

Journal of cancer research and clinical oncology·2026

Same author

Comparative evaluation of large language models for generating CAD-RADS 2.0-compliant diagnostic conclusions in cardiac CT reports.

Insights into imaging·2026

Same author

Cardiac imaging in hypertrophic cardiomyopathy and cardiac amyloidosis: a narrative review.

Frontiers in cardiovascular medicine·2026

Same author

Rare Combination of Partial ARCAPA and Dual LAD: Insights into Complex Coronary Variants.

Diagnostics (Basel, Switzerland)·2026

Same author

Bilateral carotid web with associated atherosclerotic plaque.

Medical ultrasonography·2026

Same journal

The Finding of Posterior Wall Low-Voltage Zones During Cryoballoon Pulmonary Vein Isolation Facilitated by Periprocedural Electroanatomical Mapping Is Associated with a Worse Ablation Outcome.

Journal of cardiovascular development and disease·2026

Same journal

Autonomic Nervous Dysfunction and Ultra-Short-Term Heart Rate Variability in Atrial Fibrillation: Recent Advances in Early Detection.

Journal of cardiovascular development and disease·2026

Same journal

QRS-Corrected Prediction of the Diastolic Rest Period for Coronary CT Angiography in Patients with Complete Left Bundle Branch Block.

Journal of cardiovascular development and disease·2026

Same journal

Colchicine in Coronary Artery Disease-Too Much of a Good Thing?

Journal of cardiovascular development and disease·2026

Same journal

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension.

Journal of cardiovascular development and disease·2026

Same journal

Prognostic Value of the Uric Acid-to-Albumin Ratio in Patients Undergoing Successful Percutaneous Coronary Intervention for Chronic Total Occlusion.

Journal of cardiovascular development and disease·2026

See all related articles

This summary is machine-generated.

Epicardial fat density (EFD) varies significantly by heart region. Region-specific measurements using coronary CT may not accurately represent overall EFD, impacting cardiovascular disease assessment.

Area of Science:

Cardiovascular Imaging
Radiology
Biomedical Engineering

Background:

Epicardial fat density (EFD) is a marker for cardiovascular disease risk.
Accurate EFD measurement is crucial for risk stratification.
Understanding regional EFD variability is essential for precise assessment.

Purpose of the Study:

To investigate regional differences in epicardial fat density (EFD) using coronary computed tomography (CCT).
To assess the utility of region-of-interest (ROI)-based EFD measurements compared to global segmentation.
To determine if ROI measurements can reliably represent overall EFD.

Main Methods:

Retrospective analysis of 171 patients undergoing CCT.
Global EFD measured via semi-automated segmentation (3D Slicer).

Keywords:

cardiac computed tomography (CCT)epicardial adipose tissue (EAT)epicardial fat density (EFD)epicardial fat tissue (EFT)epicardial fat volume (EFV)region of interest (ROI)

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

Related Experiment Videos

Last Updated: May 20, 2025

Ultrasonic Assessment of Myocardial Microstructure

Ultrasonic Assessment of Myocardial Microstructure

Published on: January 14, 2014

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

Regional EFD measured manually in the aortic bulb, right posterolateral wall, and cardiac apex.

Main Results:

Global EFD averaged -83.92 ± 5.19 HU.
Significant regional EFD variability observed: aortic bulb (-97.54 HU), apex (-93.42 HU), right posterolateral wall (-94.99 HU).
Statistically significant differences (p < 0.000) between global and regional EFD values.

Conclusions:

Epicardial fat density exhibits significant regional heterogeneity.
ROI-based EFD measurements may not accurately reflect global EFD.
Current ROI methods might be insufficient for comprehensive cardiovascular risk assessment based on EFD.