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Related Experiment Videos

Central auditory tests and auditory nerve-brainstem evoked responses in multiple sclerosis.

O Matathias, H Sohmer, V Biton

    Acta Oto-Laryngologica
    |March 1, 1985
    PubMed
    Summary

    Auditory nerve-brainstem evoked responses (ABR) and central auditory tests (CAT) reveal significant auditory pathway dysfunction in multiple sclerosis (MS) patients, correlating with clinical findings.

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    Area of Science:

    • Neuroscience
    • Audiology
    • Clinical Neurology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Auditory pathway involvement is common in MS, but its functional impact requires detailed assessment.

    Purpose of the Study:

    • To evaluate auditory pathway function in MS patients using auditory nerve-brainstem evoked responses (ABR) and central auditory tests (CAT).
    • To correlate auditory test results with clinical neurological examinations in MS.

    Main Methods:

    • Conducted ABR, audiometric tests, CAT (including speech perception, masking level differences, and lateralization), and clinical examinations in 43 MS patients and 43 controls.
    • Compared test results between the MS group and the control group.

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    Main Results:

    • MS patients showed significant differences in ABR and CAT results compared to controls.
    • ABR and lateralization tests were abnormal in 50% of MS patients.
    • ABR, CAT, and clinical examination results were mutually correlated.

    Conclusions:

    • Demyelination in MS likely impairs impulse velocity, leading to temporal dispersion and desynchrony.
    • ABR and CAT are sensitive to synchronous neural firing and precise timing, making them valuable for diagnosing MS-related auditory dysfunction.
    • These auditory tests can aid in both neurological and audiological diagnosis of MS.