Related Experiment Video
Updated: Jun 17, 2026
07:32
Murine Flexor Tendon Injury and Repair Surgery
Published on: September 19, 2016
13.0K
Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review.
Rishith R Mereddy1, Emily E Zona1, Camille J LaLiberte1
1Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Journal of Functional Biomaterials
|March 26, 2025
Summary
This review explores using flexor digitorum superficialis (FDS) tendon autografts and biomaterials like collagen-PCL to reinforce flexor digitorum profundus (FDP) tendon repairs, aiming to improve strength and reduce complications in hand surgery.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Regenerative Medicine
Background:
- Zone II flexor digitorum profundus (FDP) tendon injuries pose significant challenges in hand surgery.
- Traditional repair methods often result in adhesions and tendon rupture, necessitating innovative solutions.
Purpose of the Study:
- To investigate the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs.
- To evaluate the integration of biomaterials, such as collagen-polycaprolactone (PCL) composites, for enhanced mechanical strength and biocompatibility.
Main Methods:
- Review of current literature on FDP tendon repair techniques.
- Evaluation of biomaterials (collagen-PCL, nanofibers, nanoparticles) for biocompatibility, mechanical properties, and degradation.
- Assessment of FDS autograft integration for reinforcing FDP repairs.
Main Results:
- Collagen-PCL composites show promise for reducing adhesions and promoting tendon healing.
- Nanomaterials offer potential for preventing adhesions and supporting cellular proliferation but face manufacturing hurdles.
- Combined approaches aim to improve surgical outcomes and minimize complications.
Conclusions:
- Biomaterial-enhanced FDP tendon repair, particularly with collagen-PCL, presents a promising strategy to overcome limitations of traditional methods.
- Further research is needed to validate these findings in biological models and assess cost-effectiveness.
- This approach has the potential to significantly advance FDP tendon repair in hand surgery.
Related Concept Videos
01:15Bones of the Upper Limb: Ulna
The ulna and radius are parallel bones of the antebrachium or the forearm. The ulna lies medially and consists of a bony tip called the olecranon process at its proximal end. This hook-like projection articulates with the olecranon fossa of the humerus and forms the "hinged" ulnohumeral part of the elbow joint. This joint facilitates forearm extension and flexion while preventing its hyperextension. Similarly, the coronoid process, another bony projection on the proximal/anterior side of the...
01:16Muscles that Move the Forearm
The muscles that move the forearms can be divided into four groups: forearm flexors, forearm extensors, forearm pronators, and forearm supinators. The flexors and extensors act on the elbow joint, while the pronators and supinators act on the radioulnar joints.
Forearm Flexors
The biceps brachii, brachialis, and brachioradialis are forearm flexors. The biceps brachii is made up of two heads. Its long head originates at the supraglenoid tubercle of the scapula, whereas that of the short head is...
Forearm Flexors
The biceps brachii, brachialis, and brachioradialis are forearm flexors. The biceps brachii is made up of two heads. Its long head originates at the supraglenoid tubercle of the scapula, whereas that of the short head is...
01:16Muscles of the Forearm that Move the Hand and Fingers
The muscles of the forearm that move the wrist, hand, and digits are numerous and diverse. They can be classified into two groups based on their location and function — the anterior and posterior compartment muscles.
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi radialis,...
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi radialis,...
01:28Muscles of the Leg that Move the Foot and Toes
The human leg comprises an intricate system of muscles that facilitate the movement of feet and toes. Within this system, the muscles are categorized into the anterior, lateral, and posterior compartments, each with a unique set of muscles carrying out specific functions.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles.
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...