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Three-Dimensional Bioprinting for Intervertebral Disc Regeneration
Md Amit Hasan Tanvir1, Md Abdul Khaleque1, Junhee Lee2
1Department of Orthopedic Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, Seoul 34943, Republic of Korea.
Journal of Functional Biomaterials
|March 26, 2025
Summary
Tissue-engineered intervertebral discs (IVDs) show promise for regenerative medicine. Combining polymers with hydrogels and decellularized extracellular matrix (dECM) bioinks enhances scaffold properties for better IVD regeneration.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Tissue Engineering
Background:
- Rising demand for organ transplants necessitates advanced tissue models.
- Tissue-engineered intervertebral disc (IVD) scaffolds require precise mechanical and biological properties.
- Current polymer scaffolds struggle to mimic the native extracellular matrix (ECM) environment.
Purpose of the Study:
- To review recent advancements in intervertebral disc (IVD) regeneration techniques.
- To identify research gaps in IVD tissue engineering.
- To propose strategies for accelerating clinical translation of IVD therapies.
Main Methods:
- Exploration of 3D bioprinting for precise cell and biomaterial organization.
- Integration of polymers with hydrogels to create advanced porous scaffolds.
- Utilization of decellularized extracellular matrix (dECM) bioinks to replicate native microenvironments.
Main Results:
- Polymer-hydrogel composites enhance cell adhesion, proliferation, and differentiation.
- dECM-derived bioinks improve cell viability, differentiation, and motility.
- Hydrogels (natural and synthetic) offer ECM-like properties and biocompatibility.
Conclusions:
- Combining polymers with hydrogels and dECM bioinks is a promising strategy for IVD regeneration.
- Addressing current limitations can accelerate the clinical application of engineered IVDs.
- Further research is needed to bridge existing gaps for successful IVD therapies.
