Architecting polyoxovanadate-based POMOF adsorbent for specific removal of creatinine

Area of Science:

• Materials Science
• Nanotechnology
• Chemical Engineering

Background:

• Metal-organic frameworks (MOFs) are promising for toxin adsorption.
• Polyoxovanadates-based MOFs (POV-MOFs) offer unique structural properties.
• Developing efficient adsorbents for uremic toxins is crucial for renal failure patients.

Purpose of the Study:

• To design and synthesize a novel POV-MOF, Ag2(Tipa)2(V6O16) (Ag-V-MOF).
• To modify the Ag-V-MOF via alkali treatment to create EAx-Ag-V materials.
• To evaluate the adsorption performance of EAx-Ag-V for creatinine, a major uremic toxin.

Main Methods:

• Synthesis of Ag-V-MOF using tri-(4-(1-H-imidazol-1-yl)phenyl)amine (Tipa) ligand.
• Alkali treatment of Ag-V-MOF to obtain EAx-Ag-V materials.
• Adsorption experiments and characterization, including fractal dimension analysis.
• Application of definitive screening design (DSD) and central composite rotatable design (CCRD) for statistical modeling.

Main Results:

• EA3-Ag-V demonstrated a maximum creatinine adsorption capacity of 140.45 mg g⁻¹.
• The adsorbent exhibited good reusability and stable performance across a wide pH range.
• Statistical models effectively determined the influence of co-existing substances on adsorption.

Conclusions:

• EA3-Ag-V is a highly effective adsorbent for creatinine removal.
• The adsorption mechanism involves π-π interaction, H-bonding, and electrostatic attraction.
• This POV-MOF shows significant potential for improving hemodialysis treatments.