Combined treatment strategy of hydrogel dressing and physiotherapy for rapid wound healing

Wound care for open wounds is essential for reducing pain, protecting open wounds, speeding up the healing process and avoiding scar formation. Among the various three-dimensional (3D) carrier biomaterials such as films, sponges, and hydrogels, hydrogels are chemically and physically most similar to the natural extracellular matrix (ECM). Meanwhile, hydrogels are also common 3D carriers that can be efficiently loaded with drugs or cells. In addition, it forms a protective barrier on the wound surface to prevent secondary external infections and has the effect of directing skin cell expansion, tissue infiltration, and wound closure. However, the role of functional drugs in wound healing also faces a number of issues such as resistance, dosage, activity, and stability; therefore, a richer array of therapies is needed for wound repair and other areas of development. Physiotherapy, also known as nonpharmacological therapy, is a commonly used clinical treatment. Recently, more and more physiotherapy have been used for wound repair due to their high efficiency and low irritation. In recent reports, many researchers have tended to use hydrogel dressings in combination with physiotherapy, and this combination therapy is beneficial because it can both protect the wound microenvironment and accelerates wound healing. Therefore, this paper reviews the combined use of hydrogel dressings and physiotherapy in wound healing. We present the characteristics of hydrogel and physiotherapy and focus on the progress and problems of these two combined therapies in recent years.