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Uncovering the possible link between dietary advanced glycation end products and mortality risk: A systematic review
Hamid Ahmadirad1, Hossein Farhadnejad1, Mostafa Norouzzadeh1
1Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background:
Recently, observational studies have focused on dietary advanced glycation end products (dAGEs) as predictive risk factors for chronic diseases and their related mortality. The current systematic review and meta-analysis aimed to synthesize the available evidence and quantify the possible association of dAGEs and risk of all-cause or cause-specific mortality.
Methods:
A comprehensive and systematic search was conducted in online literature databases, including PubMed, Scopus and Web of Science until January 2025 without any language limitation. The hazard ratio (HR) with 95 % confidence interval (CI) for the included studies were extracted and converted into log HR. Also, we used a random-effects model with inverse variance weighting method to compute the pooled effect size.
Results:
Six eligible studies (including 18 reports) were included in the current meta-analysis. 111,543 participants, aged 45.6-79 years old, participated in these observational studies, and the duration of follow-up varied from 3.8 to 16 years. According to the pooled results of our analysis, no significant association was observed between dAGEs and its components with the risk of all-cause mortality (HR=1.02; 95 %CI=0.92, 1.13; I2= 73.2 %), cancer mortality (HR=1.00; 95 %CI=0.88, 1.13; I2= 41.0 %) and CVDs mortality (HR=1.16; 95 %CI=0.86, 1.55; I2=86.1 %). Sex, target population, dAGEs components, region, dAGEs assessment method, and dietary data collection methods were the sources of heterogeneity.
Conclusions:
In conclusion, our study suggested that there was no significant association between dAGEs intake and all-cause or cause-specific mortality.
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