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Updated: May 20, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
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Mask-based vs. frame-based stereotactic radiosurgery: A systematic review.

Wilson Hoyt1, Spencer Oslin1, Ozer Algan2

  • 1University of Oklahoma Health Sciences Center, Department of Neurosurgery, United States.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|March 26, 2025
PubMed
Summary
This summary is machine-generated.

Frameless mask-based stereotactic radiosurgery (SRS) offers comparable tumor control and adverse radiation effects to traditional frame-based SRS for brain metastases, suggesting it as a preferred frontline technique.

Keywords:
Brain metastasesFramelessGamma Knife IconLeksell frameStereotactic radiosurgery

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • Stereotactic radiosurgery (SRS) is a proven treatment for central nervous system disorders, including brain metastases.
  • Traditional SRS requires a Leksell frame, impacting workflow and patient comfort.
  • The Gamma Knife Icon system enables frameless mask-based SRS, but its benefits versus frame-based SRS require clarification.

Purpose of the Study:

  • To compare the efficacy and safety of mask-based versus frame-based SRS for brain metastases.
  • To evaluate tumor control and adverse radiation effects (AREs) between the two SRS techniques.

Main Methods:

  • A PRISMA-compliant systematic review of three databases (PubMed, Google Scholar, OVID Medline) was conducted.
  • Included studies quantitatively compared mask- and frame-based SRS for brain metastases.
  • Analysis focused on tumor control and AREs, specifically for single-fraction treatment plans.

Main Results:

  • Five publications met the inclusion criteria for the systematic review.
  • No statistically significant differences in tumor control were found between mask-based and frame-based SRS.
  • Similarly, no significant differences in adverse radiation effects were detected between the two techniques.

Conclusions:

  • Mask-based SRS provides comparable efficacy and safety to frame-based SRS for treating brain metastases.
  • The frameless approach offers improved convenience for patients.
  • Mask-based SRS may be considered the preferred frontline treatment for brain metastases.