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Updated: May 20, 2025
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis
Lanqing Yang1, Zhiquan Yuan1, Yanxiu Chen2
1Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, People's Republic of China.
Insights
Circular RNA hsa_circ_0099734 is linked to atrial fibrillation (AF) risk and poor outcomes like stroke and mortality in AF patients. This finding suggests hsa_circ_0099734 could be a biomarker for predicting AF and its prognosis.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Biomarker Discovery
Background:
- Atrial fibrillation (AF) is a prevalent arrhythmia associated with significant stroke risk, disability, and mortality.
- Previous research identified circular RNA (circRNA) hsa_circ_0099734 as differentially expressed in AF atrial tissue.
- This study investigates the clinical relevance of hsa_circ_0099734 in AF pathogenesis and prognosis.
Purpose of the Study:
- To determine the association between hsa_circ_0099734 and the risk of developing atrial fibrillation.
- To evaluate the prognostic value of hsa_circ_0099734 in predicting adverse outcomes in AF patients, including stroke and mortality.
- To explore the potential of hsa_circ_0099734 as a non-invasive biomarker for AF and its complications.
Main Methods:
- A 1:1 matched case-control study design was employed to assess the association between hsa_circ_0099734 and AF.
- A prospective cohort study utilized Cox proportional hazards regression to analyze the link between hsa_circ_0099734 levels and AF prognosis.
- Plasma levels of hsa_circ_0099734 were measured and correlated with clinical outcomes.
Main Results:
- Elevated plasma hsa_circ_0099734 levels were identified as an independent risk factor for AF (OR 3.23, P=0.032).
- High plasma hsa_circ_0099734 independently predicted stroke (HR 2.87, P<0.001) and all-cause mortality (HR 3.16, P<0.001) in AF patients.
- Incorporating hsa_circ_0099734 into risk scores improved prediction accuracy for adverse events in AF patients.
Conclusions:
- Plasma hsa_circ_0099734 levels are significantly associated with AF risk.
- Hsa_circ_0099734 serves as an independent predictor of stroke and all-cause mortality in individuals with AF.
- Hsa_circ_0099734 shows promise as a novel, non-invasive biomarker for early AF detection and prognosis assessment.
Background:
Atrial fibrillation (AF) is a common arrhythmia characterized by severe complications such as stroke, resulting in high disability and mortality rates. A circular RNA (circRNA) hsa_circ_0099734 was found significantly expressed in the atrial tissue of AF patients and controls in our previous work. In this study, we aim to reveal the association between hsa_circ_0099734 and AF as well as its poor prognosis, offering novel perspectives for clinical treatment.
Methods:
A 1:1 matched case-control study was designed to examine the association between hsa_circ_0099734 and AF. A prospective cohort study was conducted to investigate the association between hsa_circ_0099734 and AF prognosis using Cox proportional hazards regression analysis.
Results:
An elevated plasma level of hsa_circ_0099734 was an independent risk factor for AF in a multivariable conditional logistic regression model (OR 3.23, 95 % CI: 1.11-9.44; P = 0.032). Regarding the prognostic role of hsa_circ_0099734, the multivariable Cox regression analysis indicated that a high level of hsa_circ_0099734 in plasma was an independent risk factor for stroke in patients with AF (HR 2.87, 95 % CI: 1.90-4.35; P < 0.001), and also an independent risk factor for all-cause mortality in AF patients (HR 3.16, 95 % CI: 2.25-4.45; P < 0.001). Adding hsa_circ_0099734 to the CHA2DS2-VA score provided better reclassification and net clinical benefit than the ABC risk score.
Conclusions:
The plasma level of hsa_circ_0099734 was associated with AF risk and the occurrence of stroke or all-cause mortality in AF patients. Hsa_circ_0099734 has the potential to be a non-invasive biomarker for predicting AF and its poor prognosis.
