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Impact of Sorbs2 dysfunction on cardiovascular diseases

Xiaowei Xiong1, Hon-Chi Lee1, Tong Lu1

  • 1The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|March 26, 2025
PubMed

Insights

Cardiovascular diseases (CVDs) are a leading cause of death. This review explores how Sorbin and SH3 domain-containing protein 2 (Sorbs2) dysfunction may contribute to CVD development, highlighting genetic factors.

Area of Science:

  • Cardiovascular science and genetics.
  • Molecular biology and disease mechanisms.

Background:

  • Cardiovascular diseases (CVDs) are the primary global cause of mortality.
  • Genetic factors significantly influence CVDs, yet their precise roles are not fully understood.
  • Sorbin and SH3 domain-containing protein 2 (Sorbs2) is present in cardiovascular tissues and its malfunction is implicated in CVDs.

Purpose of the Study:

  • To review the current knowledge on the role of Sorbs2 in cardiovascular disease.
  • To elucidate the potential mechanisms by which Sorbs2 dysregulation contributes to CVD development.

Main Methods:

  • Literature review of studies investigating Sorbin and SH3 domain-containing protein 2 (Sorbs2).
  • Analysis of existing evidence on Sorbs2 expression, function, and its association with cardiovascular pathologies.
  • Synthesis of data on genetic and molecular pathways involving Sorbs2 in cardiovascular disease.

Main Results:

  • Sorbs2 is expressed in the cardiovascular system and plays a role in cellular functions relevant to heart health.
  • Evidence suggests a link between Sorbs2 genetic variations or altered expression and the pathogenesis of various CVDs.
  • Dysregulation of Sorbs2 impacts pathways crucial for cardiac structure and function.

Conclusions:

  • Sorbs2 is an emerging factor in cardiovascular disease etiology.
  • Further research into Sorbs2 mechanisms is crucial for understanding and potentially treating CVDs.
  • Targeting Sorbs2 pathways may offer novel therapeutic strategies for cardiovascular conditions.

Keywords:
Cardiovascular diseasePathophysiologySorbs2

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