Predictability of central corneal stromal thickness reduction in InnovEyes ablation profile: A retrospective study

To evaluate the predictability of the central corneal stromal thickness (CST) reduction in InnovEyes ablation profile.

The retrospective study included 118 eyes (61 patients) who underwent surgeries based on InnovEyes profile and 117 eyes (67 patients) based on the Custom-Q. The central CST, the central corneal thickness (CT) and the central corneal epithelial thickness (CET) were measured using anterior segment optical coherence tomography (AS-OCT) preoperatively and postoperatively over 3 months. The planned-achieved thickness (PAD) was calculated. Planned and achieved central CST, PAD and increase of central CET were compared.

The achieved central CST reduction was 113.60 ± 21.88 μm in the InnovEyes group, which was not significantly different from the planned (108.70 ± 19.87 μm, P = 0.075). There was a strong correlation between the achieved central CST reduction and the planned reduction in the InnovEyes group (R² = 0.884, P < 0.001), which was stronger than in the Custom-Q group (R² = 0.861, P < 0.001). The PAD of central CST reduction was -4.87 ± 8.17 μm and -4.76 ± 9.75 μm for the InnovEyes and Custom-Q groups, respectively (P = 0.966). The increase of central CET was 3.29 ± 3.97 μm in InnovEyes group and 4.39 ± 4.84 μm in Custom-Q group, with no significant difference (P = 0.064).

The InnovEyes ablation profile demonstrates good predictability of the central CST reduction, ensuring the safety of this novel profile. Besides, the InnovEyes profile may have taken postoperative corneal epithelial remodeling into consideration, and provided an enhanced pre-compensation.