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Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Atypical presentation of an atypical bacteria - Mycoplasmapneumoniae
Tanu Sagar1, Anusha Rathi1, Vinayaraj Ev1
1Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Abstract:
Mycoplasma pneumoniae (Mp) is a bacterium lacking cell wall, that causes atypical pneumonia in both children and adults, presenting as a mild to moderate illness. However, in some cases, it can result in severe pulmonary and extrapulmonary complications. Here, we report a case of Mycoplasma pneumoniae-associated facial palsy in a six-year-old child, who exhibited no significant respiratory signs or symptoms. The diagnosis was confirmed through real-time polymerase chain reaction assay of cerebrospinal fluid and throat samples. The possible correlation between Mycoplasma pneumoniae infection and different symptoms of the central nervous system should be kept in mind by the clinicians.
Insights
Mycoplasma pneumoniae can cause facial palsy in children, even without typical pneumonia symptoms. Early diagnosis via PCR is crucial for recognizing this neurological complication.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neurology
Background:
- Mycoplasma pneumoniae (Mp) is a common cause of atypical pneumonia in children and adults.
- While typically causing mild to moderate respiratory illness, Mp can lead to severe pulmonary and extrapulmonary complications.
- Neurological manifestations of Mp infection are recognized but less common.
Observation:
- A six-year-old child presented with facial palsy.
- The child had no significant respiratory signs or symptoms suggestive of pneumonia.
- Mycoplasma pneumoniae infection was suspected as the underlying cause.
Findings:
- Real-time polymerase chain reaction (PCR) assay confirmed Mycoplasma pneumoniae in the cerebrospinal fluid and throat samples.
- The findings establish a direct link between Mp infection and the child's facial palsy.
- This case highlights a rare extrapulmonary manifestation of Mycoplasma pneumoniae.
Implications:
- Clinicians should consider Mycoplasma pneumoniae infection in the differential diagnosis of facial palsy in children, especially when respiratory symptoms are absent.
- Awareness of potential central nervous system complications associated with Mp is important for timely diagnosis and management.
- Further research may elucidate the mechanisms linking Mycoplasma pneumoniae to neurological disorders.
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