Promising odor-based therapeutics targeting ectopic olfactory receptor proteins in cancer: A review

Cancer remains a formidable adversary in global health, necessitating the development of innovative strategies to curb the proliferation, invasion, and metastasis of cancer cells for effective treatment outcomes. Traditional cancer therapies often fall short in addressing the diverse therapeutic requirements of patients. Consequently, the exploration of novel therapeutic targets has become increasingly vital. Olfactory receptors (ORs) belonging to the G protein-coupled receptor (GPCR) subfamily, are present in non-nasal tissues and contribute to a wide range of physiological functions. ORs are specifically expressed in malignant tumors and have emerged as potential biomarkers for cancer detection. They can regulate diverse tumor biological behaviors and are involved in the development of malignant tumors, indicating that they might serve as potential targets for cancer treatment. This paper provides a comprehensive review of the ectopic expression of ORs, their functions in malignancies and odor-based therapeutics targeting ectopic olfactory receptors (EORs) in cancer, and aims to clarify their connection with cancer, providing new clues for probing the tumor biology and developing therapeutic strategies against cancer.