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Mapping the current knowledge on leucocytes in human breastmilk: a scoping review protocol
Claudia Angélica García-Alonso1, Brenda Jiménez-López1, Sebastián Castaño-Duque2
1Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Monterrey, Mexico.
BMJ Open
|March 26, 2025
Summary
This scoping review examines the current research on leucocytes (immune cells) in breastmilk. Understanding these cells is crucial for clarifying the immune benefits of breastfeeding in infants.
Area of Science:
- Immunology
- Lactation Biology
- Pediatric Health
Background:
- Breastfeeding is linked to improved child health outcomes.
- Breastmilk contains immune cells called leucocytes, but their role is understudied.
- The contribution of breastmilk leucocytes to immune benefits is debated.
Purpose of the Study:
- To conduct a scoping review on leucocytes in human breastmilk.
- To identify current knowledge, research gaps, and future priorities in this field.
Main Methods:
- Adherence to Joanna Briggs Institute guidelines for scoping reviews.
- Literature search of peer-reviewed articles in English, French, or Spanish.
- Databases searched include Medline, Embase, Cochrane Central, and BVS (January 2024).
Main Results:
- This section will be populated upon completion of the review.
- The review aims to synthesize existing evidence on breastmilk leucocytes.
Conclusions:
- This scoping review protocol provides a framework for understanding breastmilk leucocyte research.
- Findings will inform future research directions and clarify the role of these cells in infant immunity.
