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Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF

Senthil Selvaraj1, Lydia Coulter Kwee2, Elizabeth J Thompson3

  • 1Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Durham, North Carolina, USA; Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

JACC. Basic to Translational Science
|March 26, 2025
PubMed

Keywords:
SGLT2 inhibitoracylcarnitineheart failure with reduced ejection fractioninsulinketone bodiesmetabolomics

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