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Published on: July 27, 2010
Are There Atypical Leishmania Species Responsible for the Kala-Azar Persistence in Northeast Iran?
Reza Shafiei1, Amir Azimian2, Mahdi Mohebali3
1Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Porpuse:
Human visceral leishmaniasis (HVL) is a severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania.
Methods:
From 2013 to 2022, this study, molecular diagnosis was conducted on 50 pediatric bone marrow aspiration samples from northeast Iran, all of which had previously been confirmed to have visceral leishmaniasis. The ITS-rDNA gene and phylogenetic analysis were performed.
Results:
The results revealed that 49 samples tested positive for L. infantum species, whereas 1 sample was identified as L. major. All three L. infantum isolates showed similar haplotypes, whereas the L. major isolate exhibited nucleotide differences in the sequence analyzed.
Conclusion:
It could be concluded that visceral manifestations of cutaneous leishmaniasis in children living in endemic areas should be considered a contributing factor to the development of HVL. The present study provides a relatively comprehensive snapshot of unusual leishmania species status that could be responsible for HVL development.
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