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Cell reprogramming: methods, mechanisms and applications
Fei Zhu1, Guangjun Nie2,3
1Wisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China. Fei.Zhu@xjtlu.edu.cn.
Cell Regeneration (London, England)
|March 27, 2025
Summary
Cell reprogramming converts cell types, advancing developmental biology, regenerative medicine, and disease modeling. This review covers transcription factors, chemical molecules, biophysical cues, and biomolecular condensates in cell reprogramming.
Area of Science:
- Developmental Biology
- Regenerative Medicine
- Biotechnology
Background:
- Cell reprogramming enables cell type conversion, impacting multiple biological fields.
- It involves complex transcriptional, epigenetic, translational, and metabolic coordination.
- Recent research has focused on reprogramming facilitators, trajectories, and mechanisms.
Purpose of the Study:
- To summarize recent advances in cell reprogramming.
- To elaborate on the role of biophysical cues in cell reprogramming.
- To detail the mechanisms governing cell reprogramming, including biomolecular condensates.
Main Methods:
- Review of recent literature on transcription factor-mediated reprogramming.
- Analysis of chemical molecule-induced cell reprogramming.
- Discussion of biophysical cues and biomolecular condensates in reprogramming.
Main Results:
- Recent advances in transcription factor and chemical molecule-mediated reprogramming are summarized.
- The significant role of biophysical cues in cell reprogramming is highlighted.
- Mechanisms, including biomolecular condensates, governing cell reprogramming are detailed.
Conclusions:
- Cell reprogramming is a versatile tool with broad applications.
- Future directions include developmental biology, disease modeling, drug development, regenerative therapy, and cancer immunotherapy.
Keywords:
Biophysical regulationCancer immunotherapyCell reprogrammingCell therapyDisease modelingDrug developmentMore Related Videos
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