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Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

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Related Experiment Video

Updated: May 20, 2025

Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring

Identification of the Genes Involved in Stomatal Development via Epidermal Phenotype Scoring

Published on: January 20, 2023

Cis-regulatory dynamics in plant domestication.

Xiang Li¹, Robert J Schmitz¹

¹Department of Genetics, University of Georgia, Athens, GA 30602, USA.

Trends in Genetics : TIG

|March 27, 2025

Summary

Genetic variants in cis-regulatory elements (CREs) drive plant domestication. Understanding CREs offers insights into crop improvement and plant evolution.

Keywords:

cis-regulatory elements (CREs)crop improvement domestication syndrome evolution plant domestication single-cell genomics

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Area of Science:

Genetics
Plant Biology
Evolutionary Biology

Background:

Cis-regulatory elements (CREs) control gene expression spatiotemporally.
Genetic variations within CREs are key drivers of phenotypic changes during plant domestication.

Purpose of the Study:

To review current knowledge on genetic variants in CREs during plant domestication.
To propose future research directions for CRE biology and domestication processes.

Main Methods:

Literature review and synthesis of existing research on CREs in plant domestication.

Main Results:

Genetic variants in CREs significantly contribute to the phenotypic differences between wild and cultivated plants.
CREs play a crucial role in the domestication syndrome.

Conclusions:

Further research into CRE genetic variant generation and function is needed.
Modifying CREs holds potential for enhancing crop traits and improving agriculture.