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Updated: May 20, 2025

Imaging and Quantification of the Hepatic Vasculature of Mice Using Ultrafast Doppler Ultrasound
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Hepatic Portal Venous Perfusion Imaging Using Vessel-Labeling Super-Resolution Ultrasound.

Jinyu Yang1, Jiabin Zhang2, Jian An3

  • 1College of Engineering, Peking University, Beijing, China.

Ultrasound in Medicine & Biology
|March 27, 2025
PubMed
Summary
This summary is machine-generated.

A new ultrasound method precisely images hepatic portal vein blood flow using phase-change nanodroplets (PCNDs) and vascular labeling ultrasound (VLUS). This technique enhances visualization of liver vasculature for improved diagnosis of liver diseases.

Keywords:
Hepatic vascular imagingPortal vein perfusionSuper-resolution ultrasoundVessel-labeling ultrasound

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Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Hepatology

Background:

  • Hepatic portal vein imaging is crucial for diagnosing liver diseases like cirrhosis and tumors.
  • Current perfusion imaging methods face challenges due to the liver's dual blood supply.

Purpose of the Study:

  • To develop and validate a novel method for specific perfusion imaging of the hepatic portal vein and its downstream vessels.
  • To enable precise, non-invasive assessment of liver perfusion.

Main Methods:

  • Developed a technique using phase-change nanodroplets (PCNDs) and vessel-labeling ultrasound (VLUS).
  • Validated on healthy mice using ultrafast Doppler imaging and super-resolution ultrasound (SRUS).
  • PCNDs were injected, followed by targeted VLUS acquisition and offline analysis of arrival times.

Main Results:

  • VLUS successfully labeled hepatic portal vein branches and imaged downstream vessels in mice.
  • Demonstrated significantly enhanced downstream perfusion area brightness post-labeling.
  • Achieved millimeter-level precision with enhanced resolution when combined with SRUS.

Conclusions:

  • Proposed a novel VLUS-based method for accurate hepatic portal vein perfusion imaging.
  • The method enables specific, high-resolution imaging and precise non-invasive measurement of downstream perfusion.
  • Combining VLUS with SRUS further improves imaging resolution for liver vasculature.