Differences in Covid-19 deaths amongst cancer patients and possible mediators for this relationship
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View abstract on PubMed
Summary
This summary is machine-generated.Non-Hispanic Black cancer patients had a 6.46 times higher COVID-19 mortality rate. Comorbidities, particularly renal disease, explained 12.7% of this disparity, highlighting the need for targeted interventions.
Area Of Science
- Oncology
- Epidemiology
- Public Health
Background
- Non-Hispanic Black populations exhibit higher COVID-19 mortality rates compared to Non-Hispanic White individuals.
- Cancer is a recognized risk factor for fatal COVID-19 outcomes.
- Existing research has explored comorbidities in COVID-19 hospitalizations but not in COVID-19-related deaths.
Purpose Of The Study
- To investigate if the Charlson Comorbidity Index (CCI) and individual diseases explain the disparity in COVID-19 mortality between Non-Hispanic Black and Non-Hispanic White cancer patients.
- To identify specific comorbidities contributing to excess COVID-19 mortality in Non-Hispanic Black cancer patients.
Main Methods
- Analysis of Non-Hispanic Black and Non-Hispanic White cancer patients (aged ≥20) diagnosed between 2011-2019, who tested positive for COVID-19 through June 30, 2021.
- Utilized data from the Louisiana Tumor Registry.
- Conducted two mediation analyses: first, assessing overall comorbidity (CCI) and second, evaluating individual comorbidities' contribution to COVID-19 mortality differences.
Main Results
- Non-Hispanic Black cancer patients had a 6.46 times higher hazard rate for COVID-19 mortality than Non-Hispanic White patients.
- The Charlson Comorbidity Index (CCI) accounted for 12.7% of the observed differences in COVID-19 mortality.
- Renal disease was the most significant individual comorbidity, explaining 4.9% of the mortality difference.
Conclusions
- Comorbidities, especially renal disease, play a significant role in explaining the elevated COVID-19 mortality among Non-Hispanic Black cancer patients.
- Findings suggest that managing chronic conditions like renal disease may be crucial for developing targeted interventions to reduce COVID-19 mortality disparities.
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