Related Experiment Video

Updated: May 20, 2025

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.0K

Modifiable risk factors and plasma proteomics in relation to complications of type 2 diabetes

Ruyi Li1,2,3, Shufan Tian1,2,3, Jun Liu4

  • 1Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, and School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Nature Communications
|March 27, 2025
PubMed

Insights

Improving cardiovascular health and controlling risk factors significantly reduce complications and mortality in type 2 diabetes (T2D). Plasma proteins like uromodulin mediate these protective effects, offering new insights into T2D management.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Disease Research
  • Proteomics and Biomarker Discovery

Background:

  • Type 2 diabetes (T2D) management often overlooks combined modifiable risk factors and their impact on common complications.
  • The role of proteomics in understanding these associations and mediating disease pathways in T2D is not well-defined.

Purpose of the Study:

  • To assess the association between cardiovascular health (CVH) score and risk factor control with diabetic complications.
  • To explore the mediating role of plasma proteomics in these relationships within a large UK Biobank cohort.

Main Methods:

  • Utilized UK Biobank data (n=14,102) to analyze CVH score and risk factor control against 45 adverse outcomes over 12.4-13.4 years.
  • Employed mediation analyses in a subset (n=1287) with proteomic data to identify shared protein mediators.

Main Results:

  • Higher CVH score linked to reduced risk of 30 adverse outcomes in T2D patients.
  • Improved risk factor control associated with lower risk of 22 adverse outcomes.
  • Identified common protein mediators, including uromodulin and pro-adrenomedullin, for mortality and vascular diseases.

Conclusions:

  • Modifiable risk factors and enhanced CVH are crucial for mitigating disease burden in type 2 diabetes.
  • Plasma proteomics offers insights into the biological mechanisms underlying T2D complications and mortality.

More Related Videos

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.4K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

488

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
494
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
833
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.7K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
216