Related Experiment Video

Updated: May 20, 2025

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
13:20

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro

Published on: July 17, 2018

10.3K

The role of chloride intracellular channel 4 in tumors

Xin Li1, Yongfeng Wang1, Minmin Ren2,3

  • 1Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan, Zunyi, 563003, Guizhou, China.

Cancer Cell International
|March 27, 2025
PubMed

Insights

Chloride intracellular channel 4 (CLIC4) plays varied roles in cancer, acting as a tumor suppressor in some and a promoter in others. Understanding CLIC4

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer incidence is rising globally, necessitating novel therapeutic targets.
  • Chloride intracellular channel 4 (CLIC4) is expressed across various tissues and influences apoptosis, angiogenesis, and cytoskeleton regulation.
  • CLIC4's role in cancer is context-dependent, with varied expression patterns observed in different tumor types.

Purpose of the Study:

  • To review the multifaceted role of Chloride intracellular channel 4 (CLIC4) in various cancers.
  • To explore the diagnostic and therapeutic potential of CLIC4 in oncology.
  • To elucidate the mechanisms underlying CLIC4 dysregulation in solid tumors.

Main Methods:

  • Literature review of studies investigating CLIC4 expression and function in cancer.
  • Analysis of CLIC4's involvement in cancer cell growth, migration, and invasion.
  • Examination of CLIC4's potential as a therapeutic target and biomarker.

Main Results:

  • CLIC4 exhibits differential expression in cancers; it is downregulated in gastric, skin, and prostate cancers (suggesting a tumor suppressor role), but overexpressed in pancreatic, ovarian, and breast cancers (indicating a cancer-promoting role).
  • Dysregulated CLIC4 expression is linked to cancer cell growth, migration, and invasion through various mechanisms.
  • CLIC4's varied functions highlight its complex involvement in tumorigenesis.

Conclusions:

  • CLIC4 represents a promising therapeutic target and a potential biomarker for specific cancer types.
  • Targeting CLIC4 expression may offer a novel therapeutic strategy for certain tumors.
  • Further research into CLIC4's precise mechanisms in different cancers is warranted for clinical applications.

More Related Videos

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

2.2K
Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.7K

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
450
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
3.4K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K