Neural modifications of transtibial prosthesis (TTP) users: an event-related potentials study

Area of Science:

• Neuroscience
• Rehabilitation Science
• Cognitive Science

Background:

• Individuals with lower-limb amputations rely on prostheses for daily activities.
• Transtibial prosthesis (TTP) users face challenges in motor control and cognitive function compared to able-bodied individuals.
• Understanding neural mechanisms in TTP users can advance rehabilitation strategies.

Purpose of the Study:

• To investigate neuroplasticity in TTP users.
• To analyze event-related potentials (ERPs) using Electroencephalogram (EEG) during Go/No-Go tasks.
• To assess cognitive control and neural adaptations in TTP users.

Main Methods:

• Recruited 28 TTP users and 28 able-bodied controls.
• Recorded EEG during resting states and a Go/No-go task.
• Analyzed ERPs, specifically N2 and P3 amplitudes.

Main Results:

• No significant differences in resting-state brain activity between groups.
• TTP users showed increased N2 amplitude during the Go/No-go task.
• TTP users exhibited reduced P3 amplitude compared to controls.

Conclusions:

• TTP users display neural modifications, particularly in inhibitory control, crucial for attention.
• Deficits in inhibitory control may impact decision-making and daily activities requiring sustained attention.
• Targeted interventions and cortical training may enhance cognitive control in TTP users.