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Peritoneal neutrophilic cell response in necrotizing enterocolitis
American Journal of Diseases of Children (1960)
|July 1, 1985
Summary
Neutropenia in necrotizing enterocolitis (NEC) is linked to neutrophil movement into the peritoneum. This study observed neutrophil responses in infants and rats, suggesting peritoneal neutrophil sequestration as a cause of low neutrophil counts in NEC.
Area of Science:
- Neonatal Medicine
- Immunology
- Gastroenterology
Background:
- Neutropenia (low neutrophil count) is common in neonates with necrotizing enterocolitis (NEC).
- The underlying cause of neutropenia in NEC remains unclear.
- Understanding neutrophil dynamics is crucial for managing NEC.
Purpose of the Study:
- To investigate the etiology of neutropenia in neonates with NEC.
- To examine peripheral and peritoneal neutrophil responses in infants undergoing surgery for NEC.
- To utilize a rat model to study neutrophil mobilization and consumption in the peritoneum.
Main Methods:
- Observed peripheral and peritoneal neutrophil counts in seven infants with NEC at surgery.
- Induced neutrophil mobilization in a rat model using casein and Vibrio cholerae enterotoxin.
- Assessed bone marrow neutrophil stores in the animal model.
Main Results:
- Six of seven infants showed diminished peripheral neutrophil counts pre-surgery.
- Substantial mobilization of mature neutrophils into the peritoneum was observed in infants.
- Rat models demonstrated significant neutrophil mobilization into the peritoneum with both agents, decreased bone marrow stores, but no neutropenia.
Conclusions:
- Neutropenia in NEC may result from neutrophil sequestration in the peritoneum.
- Dietary protein or bacterial toxins could initiate this peritoneal neutrophil mobilization.
- Further research is needed to confirm the role of peritoneal neutrophil consumption in NEC-associated neutropenia.