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Recent Insights into Bioactive Dichalcogen Derivatives: From Small Molecules to Complex Materials
Leire Gaviria-Soteras1, Arun K Sharma2, Carmen Sanmartín1,3
1Department of Pharmaceutical Sciences, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain.
International Journal of Molecular Sciences
|March 27, 2025
Summary
Organodichalcogenides, particularly diselenides and ditellurides, show promise for treating diseases like cancer and infections. Recent research highlights their use in novel drug delivery systems and bioactive molecules.
Area of Science:
- Medicinal Chemistry
- Materials Science
- Pharmacology
Background:
- Organodichalcogenides possess diverse therapeutic properties, effective against various diseases including cancer, bacterial, viral, parasitic, and neurological conditions.
- Disulfide derivatives are a well-studied class of dichalcogenides with established therapeutic applications.
- Recent advancements focus on diselenide and ditelluride derivatives for enhanced biological activity.
Purpose of the Study:
- To review the latest research on diselenide and ditelluride derivatives with significant biological applications.
- To discuss bioactive small molecules and nanocarriers incorporating diselenide or ditelluride bonds for therapeutic use.
- To provide insights for developing novel drugs and advanced drug delivery systems.
Main Methods:
- Literature review of recent studies on organodichalcogenides, specifically diselenides and ditellurides.
- Analysis of bioactive small molecules containing diselenide or ditelluride moieties.
- Examination of diselenide and ditelluride-based nanocarriers for drug delivery applications.
Main Results:
- Diselenide and ditelluride derivatives exhibit broad-spectrum therapeutic potential.
- Novel nanocarrier systems incorporating these bonds offer advanced drug delivery advantages.
- A range of small molecules and complex materials demonstrate promising biological activities.
Conclusions:
- Diselenide and ditelluride compounds represent a valuable class of therapeutic agents.
- The development of nanocarriers based on these structures is a promising area for drug delivery.
- Continued research into these compounds could lead to new treatments for various diseases.
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