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Cartilage Oligomeric Matrix Protein Promotes Radiation Resistance in Non-Small Cell Lung Cancer In Vitro.

Kaitlyn E Reno1, Alicia Costa-Terryll1, Sun H Park1

  • 1Department of Radiation Oncology, Wake Forest University School of Medicine, 1 Medical Center Blvd, Winston Salem, NC 27157, USA.

International Journal of Molecular Sciences
|March 27, 2025
PubMed
Summary

Cartilage oligomeric matrix protein (COMP) enhances non-small cell lung cancer (NSCLC) progression and radiation resistance. Inhibitors targeting COMP signaling pathways reverse these effects, offering potential therapeutic strategies.

Keywords:
cartilage oligomeric matrix proteininvasionnon-small cell lung cancerproliferationradiation resistance

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Area of Science:

  • Oncology
  • Cancer Biology
  • Extracellular Matrix Research

Background:

  • Cartilage oligomeric matrix protein (COMP) is linked to poor outcomes in several cancers.
  • Its role in non-small cell lung cancer (NSCLC) progression and radiation response is unexplored.

Purpose of the Study:

  • To investigate the association between COMP and increased progression and radiation resistance in NSCLC.
  • To evaluate the therapeutic potential of COMP-targeting inhibitors.

Main Methods:

  • Assessed proliferation, migration, invasion, and viability of NSCLC cells with COMP manipulation and radiation.
  • Utilized exogenous COMP, COMP-overexpressing cells, and COMP signaling pathway inhibitors (Src, PI3k).
  • Conducted proteomics on COMP- and radiation-treated A549 cells.

Main Results:

  • COMP overexpression or treatment increased NSCLC proliferation, migration, invasion, and viability under radiation.
  • Src or PI3k inhibition reversed COMP-mediated protection and progression.
  • Proteomics revealed COMP promotes oxidative phosphorylation and drug resistance pathways.

Conclusions:

  • COMP overexpression and exogenous COMP protect NSCLC cells against radiation in vitro.
  • Inhibitors targeting COMP signaling pathways can reverse COMP-mediated protection and progression, suggesting therapeutic avenues.