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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Study of thermodynamic, mechanical, photo-catalytic, optoelectronic and thermoelectric properties of ferromagnetic CoSc<sub>2</sub>(S/Se)<sub>4</sub> spinels for energy conversion devices: DFT + mBJ calculations.

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Correction: Akter et al. Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations. <i>Curr. Issues Mol. Biol.</i> 2025, <i>47</i>, 716.

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Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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Prunin: An Emerging Anticancer Flavonoid.

Juie Nahushkumar Rana1, Sohail Mumtaz2

  • 1Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.

International Journal of Molecular Sciences
|March 27, 2025
PubMed
Summary
This summary is machine-generated.

Prunin, a plant-derived flavonoid, shows promising anticancer effects by modulating cellular pathways. This review explores its potential as a safe, effective cancer therapy and adjunctive treatment, enhanced by nanoformulations.

Keywords:
anticancercombination therapyflavonoidnanoformulationnatural compoundsprunin

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Area of Science:

  • Natural product chemistry
  • Pharmacology
  • Oncology

Background:

  • Developing safe and effective cancer therapies remains critical.
  • Flavonoids, like prunin, are plant-derived compounds with potential therapeutic benefits.
  • Prunin's anticancer mechanisms and biomedical applications require further scientific investigation.

Purpose of the Study:

  • To review the therapeutic potential of prunin as an anticancer agent.
  • To elucidate the molecular mechanisms underlying prunin's anticancer effects.
  • To explore prunin's role in adjunctive cancer therapy and innovative delivery systems.

Main Methods:

  • Literature review of prunin's pharmacological properties.
  • Analysis of prunin's effects on key cellular pathways.
  • Discussion of prunin's potential in combination therapies and nanoformulations.

Main Results:

  • Prunin exhibits antioxidant, anti-inflammatory, and anticancer properties.
  • Prunin modulates key cellular pathways involved in cancer progression.
  • Prunin may enhance conventional treatment responses and overcome drug resistance.

Conclusions:

  • Prunin demonstrates significant therapeutic potential as a selective and safe anticancer agent.
  • Further research into prunin's molecular mechanisms and delivery systems is warranted.
  • Prunin-based therapies, including nanoformulations, could advance cancer treatment strategies.