Enhancing Cervical Cancer Screening: New Diagnostic Methodologies, Triage, and Risk Stratification in Prevention and
Nazira Kamzayeva1, Gauri Bapayeva1, Milan Terzic1,2
1Clinical Academic Department of Women's Health, CF "University Medical Center", Astana 010000, Kazakhstan.
Life (Basel, Switzerland)
|March 27, 2025
Summary
Human papillomavirus (HPV) causes cervical cancer. This review covers global HPV prevalence, prevention strategies, and new diagnostic tools to improve early detection and patient care.
Area of Science:
- Oncology
- Virology
- Public Health
Background:
- Human papillomavirus (HPV) is a primary cause of cervical cancer.
- Understanding HPV's global prevalence and pathophysiology is crucial for effective prevention.
Purpose of the Study:
- To review current evidence on global HPV prevalence, genotypes, and disease mechanisms.
- To examine advances in diagnostics and psychosocial support for HPV management.
- To discuss strategies for enhancing cervical cancer screening and prevention.
Main Methods:
- Narrative review synthesizing existing research on HPV infection.
- Analysis of epidemiological data on HPV prevalence and genotype distribution.
- Evaluation of novel diagnostic techniques and self-sampling methods.
Main Results:
- High-risk HPV genotypes are key in cervical carcinogenesis.
- Cervicovaginal microbiota and co-infections influence HPV persistence.
- New diagnostic assays show promise for improved screening accuracy.
- Self-sampling techniques can increase screening accessibility.
Conclusions:
- A multidisciplinary approach integrating diagnostics, prevention, and psychosocial support is essential.
- Targeted prevention and improved screening are vital to reduce HPV-associated disease burden.
- Addressing regional variations in HPV epidemiology is key for global health strategies.
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