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ANXA2 Protein and Its Role in Neurodegeneration Processes

Suzanna A Partevian1, Petr A Slominsky1, Maria I Shadrina1

  • 1National Research Centre "Kurchatov Institute", 2 Kurchatova Sq., 123182 Moscow, Russia.

Life (Basel, Switzerland)
|March 27, 2025
PubMed

Insights

Annexin A2 (ANXA2) protein is linked to cancer and neurodegenerative diseases like Parkinson's. Further research is needed to confirm ANXA2's role in neurological pathologies.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Oncology

Background:

  • Annexin A2 (ANXA2) is a multifunctional protein involved in cellular processes like transport and remodeling.
  • ANXA2's role in oncogenesis is established in glioblastoma, astrocytoma, and breast cancer.
  • Emerging evidence suggests ANXA2 involvement in neurodegenerative diseases.

Purpose of the Study:

  • To review and analyze the existing data on ANXA2's function in cellular processes.
  • To explore the potential role of ANXA2 in the pathogenesis of neurological disorders.
  • To highlight the need for experimental validation of correlative findings.

Main Methods:

  • Comprehensive literature review and data analysis.
  • Examination of ANXA2's involvement in cellular mechanisms.
  • Analysis of studies linking ANXA2 to tauopathies and Parkinson's disease.

Main Results:

  • ANXA2 participates in key cellular functions, including vesicular transport, antioxidant defense, and actin remodeling.
  • ANXA2 is implicated in the progression of certain cancers.
  • Correlative data suggests ANXA2 may contribute to tauopathies and Parkinson's disease pathogenesis.

Conclusions:

  • Disruption of ANXA2-related cellular processes may contribute to neurological pathologies.
  • ANXA2 is a potential target for understanding and treating neurodegenerative diseases.
  • Further experimental validation is crucial to elucidate ANXA2's precise role in neurological conditions.
Keywords:
ANXA2Alzheimer’s diseaseParkinson’s diseaseneurodegenerationtauopathies

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