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Post-COVID-19 Pandemic Sequelae in Liver Diseases
1Department of Life Science, Health and Health Professions, Link Campus University, 00165 Roma, Italy.
Life (Basel, Switzerland)
|March 27, 2025
Summary
The COVID-19 pandemic can cause long-term liver damage, including worsening existing liver conditions or causing new ones like fatty liver disease. This review examines the mechanisms and consequences of these hepatic manifestations.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- COVID-19 is linked to adverse liver outcomes, particularly in patients with pre-existing liver conditions.
- Long COVID-19 can manifest as hepatic issues, including exacerbations of chronic liver diseases or new-onset liver conditions.
- The virus utilizes ACE2 and TMPRSS2 receptors, present in liver cells, contributing to hepatic damage.
Purpose of the Study:
- To review the pathophysiological mechanisms of COVID-19-related liver and hepatobiliary damage.
- To explore the impact of COVID-19 on liver inflammation, fibrosis, metabolic-associated fatty liver disease (MASLD), and metabolic dysfunction-associated steatohepatitis (MASH).
- To analyze the short- and long-term sequelae of COVID-19 on liver health.
Main Methods:
- Literature search conducted on the PubMed database.
- Focus on studies published in English.
- Review of pathophysiological mechanisms, clinical implications, and sequelae of COVID-19 on the liver.
Main Results:
- Post-COVID-19 liver findings include steatosis and necroinflammation.
- Alterations in inflammation, cytolysis, and cholestasis indices are observed.
- Increased risk of hepatobiliary pathologies, including secondary biliary cholangitis and worsening of MASLD, is noted.
Conclusions:
- COVID-19 poses significant short- and long-term risks to liver health.
- Understanding these hepatic manifestations is crucial for managing patients post-COVID-19.
- Further research is needed to fully elucidate the long-term impact on liver diseases, especially MASLD and MASH.
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