The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans: A Descriptive...

Area of Science:

• Microbiology
• Oncology
• Gastroenterology

Background:

• Colorectal cancer (CRC) is a significant global health concern.
• The role of microorganisms in CRC development is an area of active research.
• Understanding microbial influence is key to developing preventative strategies.

Purpose of the Study:

• To identify specific microorganisms associated with colorectal cancer (CRC).
• To investigate the prevalence of bacteria in healthy mucosa versus tumor tissue.
• To explore the potential of microbiological analysis for CRC prevention.

Main Methods:

• Microbiological analysis of tissue samples from CRC patients.
• Swabs collected from healthy mucosa, tumor surface, and tumor center.
• Comparison of microbial composition across different sample types.

Main Results:

• Escherichia coli was the most prevalent bacterium in healthy mucosa (70.5%) and tumor tissue (72.7% surface, 77.3% center).
• Enterococcus spp. and Klebsiella/Enterobacter were also common in all sample types.
• Pseudomonas aeruginosa was detected in tumor tissue but not in healthy mucosa.

Conclusions:

• Specific bacterial species, such as E. coli, are strongly associated with CRC.
• Microbial analysis holds potential for early detection and prevention of colorectal cancer.
• Further research into the dual role of bacteria (promoting vs. suppressing tumors) is warranted.