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The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans: A Descriptive
Dragan M Nikolic1,2,3, Stojan Latincic1,3,4, Jelena Jevtovic3,5
1Faculty of Medicine, University of Belgrade, Dr Subotica 9, 11000 Belgrade, Serbia.
Background:
The aim of this study is to determine which types of microorganisms influence the onset and development of colorectal cancer (CRC) in humans.
Methods:
In patients with CRC, three swabs were taken for microbiological analysis during surgical removal of the cancer: the first swab from the surface of the healthy intestinal mucosa, the second from the surface of the tumor, and the third from the middle of the tumor tissue.
Results:
In the healthy mucosa of the colon, the most prevalent microorganism was Escherichia coli at 70.5%, followed by Enterococcus spp. (47.7%) and Klebsiella/Enterobacter (20.5%). Microbiological analysis of the swabs from the surface of the tumor tissue showed that E. coli was the most prevalent at 72.7%, followed by Enterococcus spp. at 40.9%, Klebsiella/Enterobacter at 25%, and Pseudomonas aeruginosa at 20%. In the center of tumor tissue, E. coli was the most prevalent at 77.3%, followed by Enterococcus spp. at 47.7%, Klebsiella at 27%, and Pseudomonas aeruginosa at 18.2%.
Conclusion:
Certain types of bacteria can influence the emergence and development of cancer, while other types can suppress the development of tumor tissue. Microbiological analysis of human stool samples can prevent the development of CRC.
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