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New Horizon in Selective Tocols Extraction from Deodorizer Distillates Under Mild Conditions by Using Deep Eutectic
Dian Maria Ulfa1,2,3, Asep Bayu2,4, Siti Irma Rahmawati2,4
1Faculty of Pharmacy, Cluster of Health Sciences Building, Universitas Indonesia, Depok 16424, West Java, Indonesia.
Molecules (Basel, Switzerland)
|March 27, 2025
Summary
Deep eutectic solvents (DESs) offer a green chemistry approach for efficiently extracting vitamin E (tocols) from deodorizer distillates. This review explores DESs
Area of Science:
- Green Chemistry
- Natural Product Extraction
- Solvent Technology
Background:
- Tocols, commonly known as vitamin E (comprising tocopherols and tocotrienols), are valuable compounds.
- Deodorizer distillates (DDs) from oil refining are an abundant and economical feedstock for tocol extraction.
- Traditional extraction methods face limitations in efficiency and environmental impact.
Purpose of the Study:
- To review the potential of Deep Eutectic Solvents (DESs) for selective and efficient tocol extraction from DDs.
- To discuss the mechanisms of DESs in tocol extraction, considering intermolecular interactions.
- To explore different DES application systems (mono-phasic, in situ, bi-phasic) and their effectiveness.
Main Methods:
- Review of existing literature on DES applications for tocol extraction from DDs.
- Analysis of intermolecular interactions (H-bond, van der Walls, misfit) between DES components and tocols.
- Evaluation of DES properties for selective and efficient extraction under mild conditions.
Main Results:
- DESs demonstrate promising performance for selective and efficient tocol extraction from DDs.
- Extraction efficiency is influenced by the intrinsic properties of both DESs and tocols.
- DESs can be tuned for optimal tocol extraction under mild operational conditions.
Conclusions:
- DESs represent a viable, green alternative for extracting tocols from DDs.
- Understanding intermolecular interactions is key to optimizing DES-based tocol extraction.
- This review provides insights into DES applications for extracting phenolic natural compounds, with a note on toxicity.
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