Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential

Area of Science:

• Reproductive biology and medicine
• Assisted reproductive technologies (ARTs)
• Embryology and oocyte biology

Background:

• ARTs aim to improve success rates through various add-on techniques.
• These techniques target oocyte quality, fertilization, and embryo development.
• Current methods focus on optimizing in vitro fertilization (IVF) protocols and embryo selection.

Purpose of the Study:

• To review current add-on innovations in ART.
• To describe their mechanisms of action and potential benefits.
• To evaluate their role in increasing ART success rates.

Main Methods:

• Review of current literature on ART add-on techniques.
• Description of techniques targeting oocyte maturation, fertilization, and embryo development.
• Analysis of emerging technologies like PGT, PRP, TLI, and HA media.

Main Results:

• Preimplantation genetic testing (PGT) aids in selecting viable embryos for transfer.
• Emerging technologies like PRP, TLI, and HA media aim to enhance ovarian function, uterine receptivity, and embryo implantation.
• Evidence for some add-ons is limited, but research indicates potential for increased pregnancy and live birth rates.

Conclusions:

• ART add-on techniques offer potential improvements in oocyte and embryo quality.
• These innovations may enhance implantation potential and increase live birth rates, especially for patients with poor prognoses.
• Further research is needed to fully establish the efficacy of various add-on approaches.