Neurotrophic Receptor Tyrosine Kinase 3 as a Prognostic Biomarker in Breast Cancer Using Bioinformatic Analysis

Area of Science:

• Oncology
• Molecular Biology
• Immunology

Background:

• Neurotrophic receptor tyrosine kinase 3 (NTRK3) is vital for neural development.
• Limited research exists on NTRK3's role in cancer, particularly breast cancer (BC).

Purpose of the Study:

• To investigate NTRK3 as a potential prognostic biomarker in breast cancer.
• To explore the association between NTRK3 expression and tumor-infiltrating immune cells in BC.

Main Methods:

• Comprehensive analysis of NTRK3 expression using public databases (TIMER, GEPIA2, Kaplan-Meier Plotter).
• Exploration of correlations between NTRK3 expression and tumor-infiltrating immune cells (CD4+ T cells, CD8+ T cells, macrophages, neutrophils).

Main Results:

• Low NTRK3 expression correlated with poorer prognosis in BC.
• NTRK3 expression was associated with tumor stage, pathology, and Luminal subtype.
• NTRK3 expression positively correlated with infiltration of CD4+ T cells, CD8+ T cells, macrophages, and neutrophils in BC.

Conclusions:

• NTRK3 may function as a prognostic biomarker for breast cancer.
• NTRK3 offers insights into breast cancer tumor immunology.
• NTRK3 presents a potential diagnostic and therapeutic target for BC treatment.